skin microbiome and skin health; environmental-induced skin aging; epithelial morphogenesis and repair; autologous Adipose-Derived Regenerative Cell (ADRC) Therapy.
Dr. Jingjing Xia was trained as Bachelor in Clinical Medicine (6-year-German-Class) and Master in Science at Tongji Medical College, Huazhong University of Science & Technology in Wuhan, China. She did her clinical rotation at Wuhan Tongji Hospital and Heidelberg University Hospital (Germany). After the clinical training, she joined the Pharmacology Department in Max-Planck Institute for Heart and Lung Research (Bad Nauheim, Germany), working with Prof. Dr. Thomas Worzfeld on Epithelial Morphogenesis and Repair, and finished her PhD thesis with the highest honor “Summa Cum Laude”. Later, she worked as a postdoc in Prof. Carien Niessen's lab in CECAD-Cologne (Excellence Cluster on Cellular Stress Responses in Aging-Associated Diseases) on addressing the molecular mechanisms regulating skin barrier function. In 2016, she came back to China and joined the Wang-Krutmann joint lab at Fudan / IUF collaborative research center for genetics and environmental medicine, working on skin research. Here, she started to leverage multi-omics (metagenomics, metabolomics etc.) with Asia population to explore skin phenotypes (phenome), and later addressing the mechanism behind specific phenotypes with cell and mouse models.
Dr. Jingjing Xia joined the GBA-IPM in September 2021. Her current research interests include:
• microbiota resident in the human skin and their role in skin health (aging) and diseases (acne vulgaris): from multi-omics association study in Asia population to molecular mechanism by means of culturomics & function validation with skin models. The goal is to identify biomarkers and therapies that restore the balance between host and microbiota, including R&D Prebiotics, Probiotics and Live Biotherapeutic Products based on individual’s condition.
• Aryl hydrocarbon receptor (AHR) signaling in epidermal homeostasis and skin barrier function: based on our unpublished data, chemical compounds will be screened for drug discovery against extrinsic skin aging.
• exposome and environmental-induced skin aging: closely collaborate with Krutmann lab at IUF-Leibniz Research Institute for Environmental Medicine (Germany)*
• preclinical studies and clinical trials on Adipose Derived Regenerative cells (ADRCs) in Fibrosis diseases, i.e. Scleroderma, IPF
In the GBA-IPM, she has a strong interest in translational research and is open to collaboration with industry partners.
