Translational Bioinformatics in Psychiatry; Computational DNA Methylation; Explainable AI and Big data; Multi-omics based Epidemiology; Systems Bioinformatics in Ageing.
Dr. Junfang Chen worked as Research Associate in the Central Institute of Mental Health in Germany after obtaining his Ph.D. from Heidelberg University (Summa cum laude). Currently, he is a junior PI at the Greater Bay Area Institute of Precision Medicine (Guangzhou), and the leader of the Translational Bioinformatics in Complex Diseases research group. Over the past years, Dr. Chen has been focusing on translational bioinformatics in psychiatric research, especially the development of computational biology approaches and the application of explainable machine learning models using multi-modal data such as DNA methylome, genomics, transcriptomics, and neuroimaging, as well as clinical phenotypes, aiming at in-depth understanding of the mechanisms of mental disorders, personalized genetic or epigenetic risk prediction, and the identification of novel biomarkers (Schizophrenia Bulletin Open 2021, JAMA Psychiatry 2020, Schizophrenia Bulletin 2020, Translational Psychiatry 2018). The group is committed to developing and applying cutting-edge AI and omics data analytical methodologies to investigate the molecular mechanisms of complex psychiatric disorders and aging, aiding in advancing precision medicine.
