mainly focused on the total synthesis and SAR of natural bicyclic peptides
During his PhD theses, YAO investigated the total synthesis and structure activity relationship (SAR) of depsipeptide Coibmaide A in the research group of Prof. Liao at the Southeast University and Prof. Su at SIAT. This was followed by a postdoctoral stay at TU Berlin which was supported by AvH foundation and "UniSysCat", his research was mainly focused on the total synthesis and SAR of natural bicyclic peptides (Phalloidin and Amanitin) which envisions applying his skills into drug discovery, especially to develop novel drug conjugates between various modalities such as small molecules or peptides (cell penetrating peptides and cell targeted peptides) linked to amatoxins and phallotoxins. Currently, he is starting his independent career in Greater Bay Area Institute of Precision Medicine (Guangzhou).
1. 2018 10th International Peptide Symposium at Kyoto, Japan. (Travel Award)
2. 2017-2018 Research Postdoctoral Fellow of Alexander von Humboldt Foundation.
3. 2016 10th International Symposium for Chinese Medicinal Chemists at NationalTaiwan University. (Best Poster Award)
4. 2014-2015 Innovation Programs for Graduate Students in Jiangsu Province (KYLX_0162)
5. 2014-2015 The Chinese academy of sciences dean excellence award. (Top 1)
Gui-Yang Yao, Caroline H. Knittel, Simone Kosol, Marius T. Wenz, Bettina G. Keller, Hendrik Gruß, Alexandra C. Braun, Christian Lutz, Torsten Hechler, Andreas Pahl, and Roderich D. Süssmuth Iodine-Mediated Tryptathionine Formation Facilitates the Synthesis of Amanitins. Journal of the American Chemical Society 2021, 143, 35, 14322–14331.
Feng Qin, Cai Yi Wang, Donghwa Kim, Heng-Shan Wang, Yan-Kui Zhu, Sang Kook Lee,* Gui-Yang Yao,* and Dong Liang* Nitidumpeptins A and B, Cyclohexapeptides Isolated from Zanthoxylum nitidum var. tomentosum: Structural Elucidation, Total Synthesis, and Antiproliferative Activity in Cancer Cells. The Journal of Organic Chemistry. 2021, 86, 2, 1462–1470. (Corresponding author)
Guiyang Yao, Jan-Oliver Joswig, Bettina G. Keller, Roderich D. Süßmuth. Total Synthesis of the Death Cap Toxin Phalloidin: Atropoisomer Selectivity Explained by Molecular-Dynamics Simulations. Chemistry-A European Journal 2019, 25, 8030– 8034.
Guiyang Yao, Wei Wang, Zhehong Cheng, Chunlei Wu, Zhengyin Pan, Jiakai Liu, Ke Liu, Hongchang Li, Wu Su, Lijing Fang. Improved total synthesis and biological evaluation of coibamide A analogues. Journal of Medicinal Chemistry 2018, 61, 8908-8916.
Guiyang Yao, Zhengyin Pan, Chunlei Wu, Wei Wang, Lijing Fang, Wu Su. Efficient Synthesis and Stereochemical Revision of Coibamide A. Journal of the American Chemical Society 2015, 137,13488–13491.
