Dr. Jingjing Xia was trained as Bachelor in Clinical Medicine (6-year-German-Class) and Master in Science at Tongji Medical College, Huazhong University of Science & Technology in Wuhan, China. She did her clinical rotation at Wuhan Tongji Hospital and Heidelberg University Hospital (Germany). After the clinical training, she joined the Pharmacology Department in Max-Planck Institute for Heart and Lung Research (Bad Nauheim, Germany), working with Prof. Dr. Thomas Worzfeld on Epithelial Morphogenesis and Repair, and finished her PhD thesis with the highest honor “Summa Cum Laude”. Later, she worked as a postdoc in Prof. Carien Niessen's lab in CECAD-Cologne (Excellence Cluster on Cellular Stress Responses in Aging-Associated Diseases) on addressing the molecular mechanisms regulating skin barrier function. In 2016, she came back to China and joined the Wang-Krutmann joint lab at Fudan / IUF collaborative research center for genetics and environmental medicine, working on skin research. Here, she started to leverage multi-omics (metagenomics, metabolomics etc.) with Asia population to explore skin phenotypes (phenome), and later addressing the mechanism behind specific phenotypes with cell and mouse models.

Dr. Jingjing Xia joined the GBA-IPM in September 2021. Her current research interests include:

•     microbiota resident in the human skin and their role in skin health (aging) and diseases (acne vulgaris): from multi-omics association study in Asia population to molecular mechanism by means of culturomics & function validation with skin models. The goal is to identify biomarkers and therapies that restore the balance between host and microbiota, including R&D Prebiotics, Probiotics and Live Biotherapeutic Products based on individual’s condition.

•     Aryl hydrocarbon receptor (AHR) signaling in epidermal homeostasis and skin barrier function: based on our unpublished data, chemical compounds will be screened for drug discovery against extrinsic skin aging.

•     exposome and environmental-induced skin aging: closely collaborate with Krutmann lab at IUF-Leibniz Research Institute for Environmental Medicine (Germany)*

•     preclinical studies and clinical trials on Adipose Derived Regenerative cells (ADRCs) in Fibrosis diseases, i.e. Scleroderma, IPF

In the GBA-IPM, she has a strong interest in translational research and is open to collaboration with industry partners.

Dr. Xia was granted the Alumni Awards (2017) from the School of Medicine, Frankfurt University, the German Academic Exchange Service (DAAD) travel grant, and the ESDR travel grant etc. She is currently a member of the Society for Investigative Dermatology (SID) and the European Society for Dermatological Research (ESDR).

· Huizhen Chen, Qi Zhao, Qian Zhong, Cheng Duan, Jean Krutmann, Jiucun Wang*, Jingjing Xia*；Skin microbiome, metabolome and skin phenome, from the perspectives of skin as an ecosystem. Phenomics; 2022; https://doi.org/10.1007/s43657-022-00073-y

· Qingzhen Wei, Zhiming Li, Xiao Liu, Jean Krutmann*, Jiucun Wang*, Jingjing Xia*; Shotgun metagenomic sequencing reveals skin microbial variability from different facial sites. Frontiers in Microbiology; 2022 Jul 26; 13:933189.

· Xingyu Zhu; Liuyiqi Jiang; Qian Zhong; Xiangzhen Kong; Rui Zhang; Lingxian Zhu; Qingmei Liu; Wenyu Wu; Yimei Tan; Jiucun Wang*; Jingjing Xia*; Abnormal expression of interleukin-6 is associated with epidermal alternations in localized scleroderma. Clinical Rheumatology; 2022 Mar 12.

· Zhiming Li#; Jingjing Xia#; Liuyiqi Jiang#; Yimei Tan#; Yitai An; Xingyu Zhu; Jie Ruan; Zhihua Chen; Hefu Zhen; Yanyun Ma; Zhuye Jie; Liang Xiao; Huanming Yang; Jian Wang; Karsten Kristiansen; Xun Xu; Li Jin; Chao Nie*; Jean Krutmann*; Xiao Liu*; Jiucun Wang*; Characterization of the human skin resistome and identification of two microbiota cutotypes. Microbiome; 2021; 9(1): 47.

· Jingjing Xia; Thomas Worzfeld; Semaphorins and Plexins in Kidney Disease. Nephron; 2016; 132.

· Jingjing Xia; Jakub M Swiercz; Inmaculada Banon-Rodriguez; Ivana Matkovic; Giuseppina Federico; Tianliang Sun; Timo Franz; Cord H Brakebusch; Atsushi Kumanogoh; Roland H Friedel; Fernando Martin-Belmonte; Hermann-Josef Grone; Stefan Offermanns; Thomas Worzfeld*; Semaphorin-Plexin Signaling Controls Mitotic Spindle Orientation during Epithelial Morphogenesis and Repair. Developmental Cell; 2015; 33(3): 299-313. (F1000 recommendation)

· Junjie Luo, Shiwei Shen, Jingjing Xia, Jiucun Wang & Zhenglong Gu*; Mitochondria as the Essence of Yang Qi in the Human Body. Phenomics; 2022; https://doi.org/10.1007/s43657-022-00060-3

· Yunrong Ti#, Mengbo Yang#, Xinda Chen, Ming Zhang, Jingjing Xia, Xiangguo Lv, Dongdong Xiao*, Jiucun Wang*, Mujun Lu*; Comparison of the therapeutic effects of human umbilical cord blood-derived mesenchymal stem cells and adipose-derived stem cells on erectile dysfunction in a rat model of bilateral cavernous nerve injury. Frontiers in Bioengineering and Biotechnology; 2022; 10.

· X. Shi et al.; LDLR dysfunction induces LDL accumulation and promotes pulmonary fibrosis. Clinical and Translational Medicine; 2022; 12; e711

· Xiangguang Shi#; Qingmei Liu#; Han Zhao#; Jiaying Lu; Yan Huang; Yanyun Ma; Jingjing Xia; Mengguo Liu; Wenzhen Tu; Li Jin; Jiucun Wang; Yinhuan Zhao*; Wenyu Wu*; Increased expression of GAB1 promotes inflammation and fibrosis in systemic sclerosis. Experimental Dermatology; 2019; 28(11)：1313-1320.

· Matthias Zielonka; Jingjing Xia; Roland H. Friedel; Stefan Offermanns; Thomas Worzfeld*; A systematic expression analysis implicates Plexin-B2 and its ligand Sema4C in the regulation of the vascular and endocrine system. Experimental Cell Research; 2010; 316(15): 2477-2486.

· Thomas Worzfeld*; Jakub M Swiercz; Aycan Senturk; Berit Genz; Alexander Korostylev; Suhua Deng; Jingjing Xia; Mikio Hoshino; Jonathan A Epstein; Andrew M Chan; Brigitte Vollmar; Amparo Acker-Palmer; Rohini Kuner; Stefan Offermanns; Genetic dissection of plexin signaling in vivo. Proceedings of the National Academy of Sciences of the United States of America; 2014; 111(6): 2194-2199.

· Jialu Jin; Jing Gong; Tiejun Yin; Yanjun Lu; Jingjing Xia; Yuyuan Xie; Yong Di; Lei He; Jianli Guo; Jun Sun; Mathieu HM Noteborn; Shen Qu; PTD4-apoptin protein and dacarbazine show a synergistic antitumor effect on B16-F1 melanoma in vitro and in vivo. European Journal of Pharmacology; 2011; 654(1):17-25

王久存; 夏晶晶; Jean Krutmann; 刘晓; 钟倩; 李志明; 用于皮肤分型的标志物组合及其应用。2020-12-08; 中国; 申请专利号202011444009.3.