Principal Investigator
WANG Huawei
Research Direction

Precision delivery and cancer immunotherapy; Cell-derived delivery vehicles; Cell-derived cancer vaccines


Huawei received his Ph.D. from the Institute of Genetics and Developmental Biology, Chinese Academy of Sciences.  He was a Senior Assistant Project Scientist and Postdoctoral Scholar at the Department of Pathology, School of Medicine, University of California, San Diego.  He established the PEAK1 knockout mouse model and identified the important roles of PEAK1 in both developmental and tumor-induced angiogenesis.  He then took the lead role in developing the novel Cargocyte platform, which is a unique platform for programmable precision delivery and has great potential in treating cancer and other human diseases.  He joined the GBA-IPM in November 2021 and built up the Lab of Precision Delivery and Immunotherapy.  He publishes on cell biology, cancer biology, immunology, cell engineering and cell therapy. He has got the funding support from NSFC (General program, 2023-2026) and the Ministry of Science and Technology of China (National Science and Technology Major Project, 2023-2027).


1.     Wang H*, Alarcón C*, Liu B, Watson F, Searles S, Lee C, et al. Wang, H., Alarcón, C.N., Liu, B. et al. Genetically engineered and enucleated human mesenchymal stromal cells for the targeted delivery of therapeutics to diseased tissue. Nature Biomedical Engineering (2021). (* Co-first author)

2.     Wang H, Lapek J, Fujimura K, Strnadel J, Liu B, Gonzalez DJ, et al. Pseudopodium-enriched atypical kinase 1 mediates angiogenesis by modulating GATA2-dependent VEGFR2 transcription. Cell Discovery. 2018;4:26.

3.     Fujimura K*, Wang H*, Watson F, Klemke RL. KRAS Oncoprotein Expression Is Regulated by a Self-Governing eIF5A-PEAK1 Feed-Forward Regulatory Loop. Cancer Research. 2018;78:1444-56. (*Co-first author)

4.     Strnadel J*, Wang H*, Carromeu C, Miyanohara A, Fujimura K, Blahovcova E, et al. Transplantation of Human-Induced Pluripotent Stem Cell-Derived Neural Precursors into Early-Stage Zebrafish Embryos. Journal of Molecular Neuroscience. 2018;65:351-8. (*Co-first author)

5.     Yang L, Jama B, Wang H, Labarta-Bajo L, Zuniga E. I., and Morris G. P. TCRalpha reporter mice reveal contribution of dual TCRalpha expression to T cell repertoire and function. Proc Natl Acad Sci U S A 117, 32574-32583.

6.     Noriega-Guerra H, Cruz MC, Ribeiro PRL, Strnadel J, Wang H, Klemke RL, et al. ADAMTS-1 disrupts HGF/c-MET signaling and HGF-stimulated cellular processes in fibrosarcoma. Exp Cell Res. 2018;363:271-82.

7.     Liu C, Han TX, Stachura DL, Wang H, Vaisman BL, Kim J, et al. Lipoprotein lipase regulates hematopoietic stem progenitor cell maintenance through DHA supply. Nat Communication. 2018;9.

8.     Gilder AS, Natali L, Van Dyk DM, Zalfa C, Banki MA, Pizzo DP, Wang H, et al. The Urokinase Receptor Induces a Mesenchymal Gene Expression Signature in Glioblastoma Cells and Promotes Tumor Cell Survival in Neurospheres. Sci Rep. 2018;8:2982.

9.     Strnadel J, Choi S, Fujimura K, Wang H, Zhang W, Wyse M, et al. eIF5A-PEAK1 Signaling Regulates YAP1/TAZ Protein Expression and Pancreatic Cancer Cell Growth. Cancer Res. 2017;77:1997-2007.

10.   Fang J, Wang H, Miao L, Kuang X, Ma W, Wang C, et al. Involvement of Protein Acyltransferase ZDHHC3 in Maintaining Oocyte Meiotic Arrest in Xenopus laevis. Biology of Reproduction. 2016;95:67.

11.   Wang H, Fang JS, Kuang X, Miao LY, Wang C, Xia GL, et al. Activity of Long-Chain Acyl-CoA Synthetase Is Required for Maintaining Meiotic Arrest in Xenopus laevis. Biology of Reproduction. 2012;87.


·   Platform For Generating Safe Cell Therapeutics. United States Patent Number: US 10,927,349 B2. International patent number: WO 2019/032628 A1. Issued. 

·   Methods and Use for Bioengineering Enucleated Cells. International patent number: WO 2021/158991 A1.