Dr. Tang is a co-principal investigator in the Center for Organoid and Regeneration. Her main research interest is the regulation of lung epithelia during development and diseases, especially the roles of protein quality control and epigenetic modifications. Her future objectives are 1) to investigate the involvement of disrupted proteostasis of lung epithelia under physiological and pathological conditions; 2) to interrogate epigenetic regulation in the control of differentiation and regeneration of lung epithelia during development and injury.  

 
Dr. Tang received her B.Sc. from Tsinghua University and Ph.D. from the Molecular & Developmental Biology program at Cincinnati Children’s Hospital Medical Center. She was trained as a postdoctoral scholar in the Division of Pulmonary Biology at Cincinnati Children’s Hospital Medical Center. She joined the GBA-IPM in April 2022. She has published a series of research articles on developmental biology and won a fund from the LRRC Young Investigator Pilot Project of NHLBI (USA).

1.      Xiaofang Tang, Wei Wei, John M. Snowball, Ernesto S. Nakayasu, Sheila Bell, Charles Ansong, Xinhua Lin, Jeffrey A. Whitsett. EMC3 regulates mesenchymal cell survival via control of the mitotic spindle assembly. (Under revision)

2.      Xiaofang Tang, Timothy E. Weaver, Ernesto S. Nakayasu, Geremy Clair, John M. Snowball, Cheng-Lun Na, Karen S. Apsley, Emily P. Martin, Darrell N. Kotton, Konstantinos-Dionysios Alysandratos, Jiuzhou Huo, Jeffrey D. Molkentin, William A. Gower, Wei Wei, Xinhua Lin, Jeffrey A. Whitsett. Endoplasmic reticulum membrane complex regulates trafficking and pulmonary toxicity of the SFTPCI73T mutation. (Under revision)

3.      Qinghang Meng*, Xiaofang Tang*, James Gulick, Hanna Osinska, Jeanne James, Wei Wei, John Snowball, Ronald J. Vagnozzi, Xinhua Lin, Jeffrey Whitsett, Jeffrey Robbins, Jeffery D. Molkentin. EMC3 Regulates Protein Homeostasis in the Cardiovascular System. (*equal contribution) (Under revision)

4.      Xiaofang Tang, John M. Snowball, Yan Xu, Cheng-Lun Na, Timothy E. Weaver, Geremy Clair, Jennifer E. Kyle, Erika M. Zink, Charles Ansong, Wei Wei, Meina Huang, Xinhua Lin, Jeffrey A. Whitsett. (2017) EMC3 coordinates surfactant protein and lipid homeostasis required for respiration. Journal of Clinical Investigation 127, 4314-4325, doi:10.1172/JCI94152 (2017).

5.      Qinzhu Huang*, Xiaofang Tang*, Guolun Wang*, Yun Fan, Andreas Bergmann, Dongsheng Yan, Yi Lin, Xiaolei Ye, Xiaolan Fan, Xiangtian Zhou, Fan Lu, Jia Qu, Xinhua Lin. (2014) Ubr3 E3 ligase regulates apoptosis by controlling the activity of DIAP1 in Drosophila. Cell Death & Differentiation 21, 1961-1970. (*equal contribution)

6.      Qinghang Meng, Maureen Mongan, Jingjing Wang, Xiaofang Tang, Jinling Zhang, Winston Kao, Ying Xia. (2014) Epithelial sheet movement requires the cooperation of c-Jun and MAP3K1. Developmental Biology 395(1), 29-37.

7.      Guolun Wang*, Xiaofang Tang*, Yujie Chen, Jun Cao, Qinzhu Huang, Xuemei Ling, Wenyan Ren, Songqing Liu, Yihui Wu, Lorraine Ray, Xinhua Lin. (2014) Hyperplastic discs differentially regulates the transcriptional outputs of hedgehog signaling. Mechanisms of Development 133, 117-25. (*equal contribution)

8.      Xiaofang Tang*, Yihui Wu*, Tatyana Y. Belenkaya, Qinzhu Huang, Lorraine Ray, Jia Qu, Xinhua Lin. (2012) Roles of N-glycosylation and lipidation in Wg secretion and signaling. Developmental Biology 364, 32-41. (*equal contribution)

9.      Xiaofang Tang, Xiaolan Fan, Xinhua Lin. (2010) Regulation of Wnt secretion and distribution. In: Targeting the Wnt pathway in cancer. Springer. p. 19-33

10.   Dong Yan, Yihui Wu, Yongfei Yang, Tatyana Y. Belenkaya, Xiaofang Tang and Xinhua Lin. (2010) The cell-surface proteins Dally-like and Ihog differentially regulate Hedgehog signaling strength and range during development. Development 137, 2033-44.

11.  Wei Wang, Wenke Liu, Yue Wang, Liya Zhou, Xiaofang Tang and Hong Luo. (2010) Notch signaling regulates neuroepithelial stem cell maintenance and neuroblast formation in Drosophila optic lobe development. Developmental Biology 350, 414-28.

12.  Tatyana Y. Belenkaya, Yihui Wu*, Xiaofang Tang*, Bo Zhou, Longqiu Cheng, Yagya V. Sharma, Dong Yan, Erica M. Selva and Xinhua Lin. (2008) The retromer complex influences wnt secretion by recycling wntless from endosomes to the trans-Golgi network. Developmental Cell 14, 120-31. (*equal contribution)